Center for Multimodal Evaluation of Engineered Cartilage

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Recent Publications

Harihara Baskaran

Arnold I. Caplan

Diego Correa

Alex Huang

Jonathan E. Kenyon

Ahmad M. Khalil

Zhenghong Lee

Donald P. Lennon

Ming Li

Joseph M. Mansour

Mostafa Motavalli

Mark D. Schluchter

Rodrigo Somoza

J. Michael Sorrell

Jean F. Welter

Carl Winalski

Harihara Baskaran, Ph.D.

Chou, C.L.; Rivera, A.L.; Williams, V.; Welter, J.F.; Mansour, J.M.; Drazba, J.A.; Sakai, T.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented large-scale tissue engineered cartilage. Acta Biomater. 2017 doi: 10.1016/j.actbio.2017.07.016. [Epub ahead of print] Abstract

Chung, C.Y.; Heebner, J.; Baskaran, H.; Welter, J.F.; and Mansour, J.M.: Ultrasound elastography for estimation of regional strain of multilayered hydrogels and tissue-engineered cartilage. Ann Biomed Eng. 2015 43(12):2991-3003 Abstract

Thomas, D.G.; Yenepalli, A.; Denais, C.M.; Rape, A.; Beach, J.R.; Wang, Y.L.; Schiemann, W.P.; Baskaran, H.; Lammerding, J.; and Egelhoff, T.T.: Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion. Journal of Cell Biology. 2015, 210(4):583-594. doi: 10.1083/jcb.201502039. Abstract

Rivera, A.L. and Baskaran, H.: The effect of biomolecular gradients on mesenchymal stem cell chondrogenesis under shear stress. Micromachines 2015, 6(3):330-346. doi:10.3390/mi6030330

Prologo, J.D.; Duesler, L.; Berilla,J.A.; Baskaran, H.; Schluchter, M.D.; and Welter, J.F.: Impact of concurrent pressure and shear on MSC viability and differentiation during simulated intervertebral disk needle injection. Journal of Vascular and Interventional Radiology 2014 (Submitted)

Chou, C.L.; Rivera, A.L.; Sakai, T.; Caplan, A.I.; Goldberg, V.M.; Welter, J.F.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented cartilage extracellular matrix. Tissue Eng Part A. 2013 19(9-10):1081-1090 Abstract

Peiris, P.M.; Toy, R.; Doolittle, E.; Pansky, J.; Abramowski, A.; Tam, M.; Vicente, P.; Tran, E.; Hayden, E.; Camann, A.; Mayer, A.;, Erokwu, B.O.; Berman, Z.; Wilson, D.; Baskaran, H.; Flask, C.A.; Keri, R.A.; and Karathanasis, E: Imaging metastasis using an integrin-targeting chain-shaped nanoparticle. ACS Nano. 2012 6(10):8783-8795. Abstract

Wang, K.; Wang, J.H.; Baskaran, H.; Wang, R.; and Jurevic, R.: Effect of human beta-defensin-3 on head and neck cancer cell migration using micro-fabricated cell islands. Head Neck Oncol. 2012 28;4:41. Abstract

Maeda, T.; Sakabe, T,; Sunaga, A.; Sakai, K.; Rivera, A.L.; Keene, D.R.; Sasaki, T.; Stavnezer, E.; Iannotti, J.; Schweitzer, R.; Ilic, D.; Baskaran, H.; and Sakai, T.: Conversion of mechanical force into TGF-β-mediated biochemical signals. Curr Biol. 2011 21(11):933-941. Abstract

Toy, R.; Hayden, E.; Shoup, C.; Baskaran, H.; and Karathanasis, E.; The effects of particle size, density and shape on margination of nanoparticles in microcirculation. Nanotechnology. 2011 22(11):115101. Abstract

Sarkar, S.; Bustard, B.L.; Welter, J.F.; and Baskaran, H.: Combined experimental and mathematical approach for development of microfabrication-based cancer migration assay. Annals of Biomedical Engineering 2011 39(9):2346-2359 Abstract

Liang, W.H.; Kienitz, B.L.; Penick, K.; Welter, J.F.; and Baskaran, H.: Concentrated collagen-chondroitin sulfate scaffolds for tissue engineering applications. Journal of Biomedical Materials Research, Part A 2010 94(4):1050-1060. Abstract

Breckenridge, M.T.; Egelhoff, T.T.; and Baskaran, H.: A microfluidic imaging chamber for the direct observation of chemotactic transmigration. Biomed Microdevices. 2010 12(3):543-553. Abstract

Mazzoccoli, J.P.; Feke, D.L.; Baskaran, H.; and Pintauro, P.N.: Development of multilayered cell-hydrogel composites using an acoustic focusing technique. Biotechnol Prog. 2010 26(2):600-605. Abstract

Mazzoccoli, J.P.; Feke, D.L.; Baskaran, H.; and Pintauro, P.N.: Mechanical and cell viability properties of crosslinked low- and high-molecular weight poly(ethylene glycol) diacrylate blends. J Biomed Mater Res A. 2010 93(2):558-566. Abstract

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Arnold I. Caplan, Ph.D.

Somoza, R.A.; Correa, D.; Labat, I.; Sternberg, H.; Forrest, M.E.; Khalil, A.M.; West, M.D.; Tesar, P.; and Caplan, A.I.: Transcriptome-wide analyses of human neonatal articular cartilage and human mesenchymal stem cell-derived cartilage provide a new molecular target for evaluating engineered cartilage. Tissue Engineering, Part A, DOI: 10.1089/ten.tea.2016.0559Abstract

Correa, D.; Somoza, R.A.; and Caplan, A.I.: Non-destructive/non-invasive imaging evaluation of cellular differentiation progression during in vitro MSC-derived chondrogenesis. Tissue Eng Part A. 2017 Aug 21. doi: 10.1089/ten.TEA.2017.0125. [Epub ahead of print] Abstract

Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. (Submitted to Journal of Orthopaedic Research).

Mishra, R.; Sefcik, R.S.; Bishop, T.J.; Montelone, S.M.; Crouser, N.; Welter, J.F.; Caplan, A.I.; and Dean, D.: Growth factor dose tuning for bone progenitor cell proliferation and differentiation on resorbable poly(propylene fumarate) scaffolds. Tissue Engineering Part C Methods. 2016 22(9):904-913. Abstract

Caplan, A.I.,; Mason, C.; and Reeve, B.:The 3Rs of Cell Therapy. Stem Cells Transl Med. 2016 Aug 8. pii: sctm.2016-0180. [Epub ahead of print] Abstract

Tremolada, C.; Ricordi, C.; Caplan, A.I,; and Ventura, C.: Mesenchymal Stem Cells in Lipogems, a Reverse Story: from Clinical Practice to Basic Science.
Methods Mol Biol. 2016;1416:109-22. doi: 10.1007/978-1-4939-3584-0_6. Abstract

Shalev-Malul, G.; Soler, D.C.; Ting, A.E.; Lehman, N.A.; Barnboym, E.; McCormick, T.S.; Anthony, D.D.; Lazarus, H.M.; Caplan, A.I.; Breitman, M.; and Singer, N.G. Development of a functional biomarker for use in cell-based therapy studies in seropositive rheumatoid arthritis. Stem Cells Transl Med. 2016 5(5):628-31 Abstract

Sutton, M.T.; Fletcher, D.; Ghosh, S.K.; Weinberg, A.; van Heeckeren, R.; Kaur, S.; Sadeghi, Z.; Hijaz, A.; Reese, J.; Lazarus, H.M.; Lennon, D.P.; Caplan, A.I.; and Bonfield, T.L.: Antimicrobial properties of mesenchymal stem cells: therapeutic potential for cystic fibrosis infection, and treatment. Stem Cells Int. 2016;2016:5303048. doi: 10.1155/2016/5303048. Epub 2016 Jan 26. Abstract

Caplan A.I.: MSCs: The sentinel and safe-guards of injury. J Cell Physiol. 2016 231(7):1413-1416. Abstract

Barker, N.M.; Carrino, D.A.; Caplan, A.I.; Hurd, W.W.; Liu, J.H.; Tan, H.; and Mesiano S.: Proteoglycans in leiomyoma and normal myometrium: abundance, steroid hormone control, and implications for pathophysiology. Reprod Sci. 2016 23(3):302-9 Abstract

Correa D.; Lin, P.; Somoza, R.; Schiemann, W.P.; and Caplan, A.I.: Bone marrow Mesenchymal Stem Cells (BM-MSCs) regulate melanoma cancer cell extravasation at their perivascular niche. International Journal of Cancer, 2016 15;138(2):417-27Abstract

Caplan, A.I.: Adult mesenchymal stem cells: when, where, and how. Stem Cells International 2015, 2015:628767. doi: 10.1155/2015/628767. Abstract

Caplan, A.I. and Sorrell, J.M.: The MSC curtain that stops the immune system. Immunol Lett. 2015 168(2):136-9. Abstract

Murrell, W.D.; Anz, A.W.; Badsha, H.; Bennett, W.F.; Boykin, R.E.; and Caplan, A.I.: Regenerative treatments to enhance orthopedic surgical outcome. PMR 2015, 7(20):S41-S52.

Caplan, A.I. and Hariri, R.: Body management: mesenchymal stem cells control the internal regenerator. Stem Cells Translational Medicine 2015, 4(7):695-701. doi: 10.5966/sctm.2014-0291. Abstract

Hung, B.P.; Hutton, D.L.; Kozielski, K.L.; Bishop, C.J.; Naved, B.; Green, J.J.; Caplan, A.I.; Gimble, J.M.; Dorafshar, A.H.; and Grayson, W.L.: Platelet-derived growth factor BB enhances osteogenesis of adipose-derived but not bone marrow-derived mesenchymal stromal/stem cells. Stem Cells 2015, 33(9):2773-2784. doi: 10.1002/stem.2060.Abstract

Giori, A.; Tremolada, C.; Vailati, R.; Navone, S.E.; Marfia, G.; and Caplan, A.I.: Recovery of function in anal incontinence after micro-fragmented fat graft (Lipogems) injection: Two years follow up of the first 5 cases. CellR4 2015, 3(2):e1544.

Lin, P.; Caplan, A.I; and Ruoslahti, E.: Delivery and targeting of therapeutic cells. In: Stem Cells in Regenerative Medicine: Science, Regulation and Business Strategies. Vertes, A.; Qureshi, N.; Caplan, A.; and Babiss, L. (Eds), John Wiley & Sons, 2015, Chapter 21:389-398

Caplan, A.I.: MSCs: The new medicine. In: Stem Cells in Regenerative Medicine: Science, Regulation, and Business Strategies. Vertes, A.; Qureshi, N.; Caplan, A.; and Babiss, L. (Eds), John Wiley & Sons, Ltd 2015, Chapter 23:415-421 (invited chapter)

Caplan, A.I.: Are all adult stem cells the same? Regenerative Engineering and Translational Medicine 2015, (Accepted)

Dean, D.; George, J.E.; Varghai, D.; Cooke, M.N.; Min, K.-J.; Dennis, J.; Fisher, J.P., Rimnac, C.M.; Lennon, D.P.; Sun, J.; Mikos, A.G.; and Caplan, A.: Additive Manufacturing of Poly(Propylene Fumarate) Tissue engineered constructs for a canine critical size cranial defect. Acta Biomaterialia, (Submitted 2014).

Caplan, A.I.: Adult mesenchymal stem cells and women’s health. Menopause. 2015 (2):131-135. Abstract

Adorno-Cruz, V.; Kibria, G.; Liu, X.; Doherty, M.; Junk, D.J.; Guan, D.; Hubert, C.G.; Venere, M.; Mulkearns-Hubert, E.; Sinyuk, M.; Alvarado, A.; Caplan, A.I.; Rich, J.N.; Gerson, S.L.; Lathia, J.D.; and Liu, H.: Cancer stem cells: Targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance. Cancer Res. 2015 pii: canres.3225.2014 Abstract

Correa, D.; Somoza, R.A.; Lin, P.; Rom, E.; Duesler, L.; Welter, J.F.; Yayon, A.; and Caplan. A.I.: Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. Osteoarthritis and Cartilage, 2014 pii: S1063-4584(14)01336-3 Abstract

Holt, V.; Caplan, A.I.; and Haynesworth, S.E.: Identification of a subpopulation of marrow MSC-derived medullary adipocytes that express osteoclast-regulating molecules: marrow adipocytes express osteoclast mediators. PLoS One. 2014 Oct 10;9(10):e108920 Abstract

Cheng, J.W.; Sadeghi, Z.; Levine, A.D.; Penn, M.S.; von Recum, H.A.; Caplan, A.I.; and Hijaz, A.: The role of CXCL12 and CCL7 chemokines in immune regulation, embryonic development, and tissue regeneration. Cytokine. 2014 69(2):277-283. Abstract

Somoza, R.; Welter, J.; Correa, D.; and Caplan, A.: Chondrogenic differentiation of Mesenchymal Stem Cells: unfulfilled expectations and new challenges. Tissue Engineering part B, 2014 20(6):596-608. Abstract

Wallace, J.; Wang, M.O.; Thompson, P.; Busso, M.; Belle, V.; Mammoser, N.; Kim, K.; Fisher, J.P.; Siblani, A.; Xua, Y.; Welter, J.F.; Lennon, D.P.; Sun, J.; Mikos, A.G.; Caplan, A.I.; Dean, D.: Validating continuous digital light processing (cDLP) additive manufacturing accuracy and tissue engineering utility of a dye-initiator package. Biofabrication 2014 6(1):015003 Abstract

Caplan, A.I. and West, M.D.: Progressive approval: A proposal for a new regulatory pathway for regenerative medicine. Stem Cells Transl Med. 2014 3(5):560-563.Abstract

Murphy, M.B.; Moncivais, K.; and Caplan, A,I.: Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med. 2013 15;45:e54. doi: 10.1038/emm.2013.94. Abstract

Lin, P.; Correa, D.; Kean, T.J.; Awadallah, A.; Dennis, J.E.; and Caplan, A.I.: Serial transplantation and long-term engraftment of intra-arterially delivered clonally derived mesenchymal stem cells to injured bone marrow. Mol Ther. 2014 22(1):160-168.Abstract

Tremolada, C.; Bianchi, F.; Ventura, C.; DiVito, C.; Capanella, R.; Navone, S.E.; Marfia, G.; and Caplan, A.I.: Adipose mesenchymal stem cells and “regenerative adipose tissue graft” (Lipogems™) for musculoskeletal regeneration. Journal of Musculoskeletal Diseases 2014, 3(2):57-67.

Dimarino, A.M.; Caplan, A.I.; and Bonfield, T.L.: Mesenchymal stem cells in tissue repair. Front Immunol. 2013 Sep 4;4:201. Review. Abstract

Kean, T.J.; Lin, P.; Caplan, A.I.; and Dennis, J.E.: MSCs: Delivery routes and engraftment, cell-targeting strategies, and immune modulation. Stem Cells Int. 2013:732742. doi: 10.1155/2013/732742. Epub 2013 Aug 13. Abstract

Rowland, C.R.; Lennon, D.P.; Caplan, A.I.; and Guilak, F.: The effects of crosslinking of scaffolds engineered from cartilage ECM on the chondrogenic differentiation of MSCs. Biomaterials. 2013 34(23):5802-5812. Abstract

Crapnell, K.; Blaesius, R.; Hastings, A.; Eng, M.; Lennon, D.P.; Caplan, A.I.; and Bruder, A.P.: Growth, differentiation capacity, and function of mesenchymal stem cells expanded in serum-free medium developed via combinatorial screening. Exp Cell Res. 2013 319(10):1409-1418. Abstract

Caplan, A.: MSCs as Therapeutics. In: Stem Cell Biology and Regenerative Medicine. Mesenchymal stromal cells: biology and clinical applications. Hematti, P. and Keating, A. (Eds.), Springer Science+Business Media New York, 2013 Chapter 5: 79-90.

Caplan, A.I.: MSCs: The new medicine (invited chapter) In: Stem Cells in Regenerative Medicine: Science, Regulation, and Business Strategies. A Vertes (Eds), John Wiley & Sons, Ltd, Accepted 2012.

Caplan, A.I.: Mesenchymal Stem Cells in Regenerative Medicine. In: Handbook of Stem Cells, Vol 2, eds A Atala and R Lanza, eds. Academic Press 2012, Chapter 43:493-502.

da Silva Meirelles, L.; Caplan, A.I.; and Nardi, N.B.: Pericytes as the source of mesenchymal stem cells. In: Resident Stem Cells and Regenerative Therapy, Goldenberg, R.C. and de Carvalho, A.C.C., eds. Elsevier Inc. 2012, Chapter 12:233-250.

Caplan, A.I.: Adult mesenchymal stem cells and the NO pathways. Proceedings of the National Academy of Science U S A. 2013, 110(8):2695-2696. Link

Lin, P.; Lin, Y.; Lennon, D.P.; Correa, D.; Schluchter, M.; and Caplan, A.I.: Efficient lentiviral transduction of human mesenchymal stem cells that preserves proliferation and differentiation capabilities. Stem Cells Translational Medicine 2012, 1(12):886-897.Abstract

Lennon, D.P.; Schluchter, M.D.; and Caplan, A.I.: The effect of extended first passage culture on the proliferation and differentiation of human marrow-derived mesenchymal stem cells. Stem Cells Translational Medicine 2012, 1(4):279-288. Abstract

Chou, C.L.; Rivera, A.L.; Sakai, T.; Caplan, A.I.; Goldberg, V.M.; Welter, J.F.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented cartilage extracellular matrix. Tissue Engineering Part A. 2013, 19(9-10):1081-1090. Abstract

Dong, F. and Caplan, A.I.: Cell transplantation as an initiator of endogenous stem cell-based tissue repair. Curr Opin Organ Transplant. 2012 17(6):670-674. Abstract

Ousema, P.H.; Moutos, F.T.; Estes, B.T.; Caplan, A.I.; Lennon, D.P.; Guilak, F,; and Weinberg, J.B.: The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds. Biomaterials 2012, 33(35):8967-8974. Abstract

Lizier, N.F.; Kerkis, A.; Gomes, C.M.; Hebling, J.; Oliveira, C.F.; Caplan, A.I.; and Kerkis, I.” Scaling-up of dental pulp stem cells isolated from multiple niches. PLoS One 2012, 7(6):e39885. Abstract

Bai, L.; Lennon, D.P.; Caplan, A.I.; DeChant, A.; Hecker, J.; Kranso, J.; Zaremba, A.; and Miller, R.H.: Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models. Nat Neurosci. 2012 15(6):862-870. Abstract

Carrino, D.A.; Mesiano, S.; Barker, N.M.; Hurd, W.W.; and Caplan, A.I.: Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition. Biochemical Journal 2012, 443(2):361-368. Abstract

Kerkis, I. and Caplan, A.I.: Stem cells in dental pulp of deciduous teeth. Tissue Engineering Part B 2012, 18(2):129-138. Abstract

Sorrell, J.M.; Baber, M.A.; Traktuev, D.O.; March, K.L.; and Caplan, A.I.: The creation of an in vitro adipose tissue that contains a vascular-adipocyte complex. Biomaterials 2011, 32(36):9667-9676. Abstract

Lin, P.; Correa, D.; Lin, Y.; and Caplan, A.I.: Polybrene inhibits human mesenchymal stem cells proliferation during lentiviral transduction. PLoS One 2011 6(8):e23891. Abstract

Caplan, A.I. and Correa, D.: The MSC: An injury drugstore. Cell Stem Cell 2011, 9(1):11-15. (Invited Perspective article.) Abstract

Caplan, A.I. and Correa, D.: PDGF in bone formation and regeneration: new insights into a novel mechanism involving mscs. Journal of Orthopaedic Research 2011 29(12):1795-1803. (invited Perspective article) Abstract

Walker, J.M.; Myers, A.M.; Schluchter, M.D.; Goldberg, V.M.; Caplan, A.I.; Berilla, J.A.; Mansour, J.M.; and Welter, J.F.: Nondestructive Evaluation of Hydrogel Mechanical Properties Using Ultrasound. Annanls of Biomedical Engineering 2011, 39(10):2521-2530. Abstract

Pineau, N.; Carrino, D.A.; Caplan, A.I.; and Breton, L.: Biological evaluation of a new C-xylopyranoside derivative (C-Xyloside) and its role in glycosaminoglycan biosynthesis. European Jouranl of Dermatology 2011, 21(3):359-370. Abstract

Singer, N.G. and Caplan, A.I.: Mesenchymal stem cells: mechanisms of inflammation. Annual Review of Pathology 2011, 28;6:457-478. Abstract

Carrino, D.A.; Calabro, A.; Darr, A.B.; Dours-Zimmermann, M.T.; Sandy, J.D.; Zimmermann, D.R.; Sorrell, J.M.; Hascall, V.C.; and Caplan, A.I.: Age-related differences in human skin proteoglycans. Glycobiology. 2011 21(2):257-268. Abstract

Bonfield, T.L.; Nolan Koloze, M.T.; Lennon, D.P.; and Caplan, A.I.: Defining human mesenchymal stem cell efficacy in vivo. J Inflamm (Lond). 2010 25;7:51. Abstract

Sorrell, J.M. and Caplan, A.I.: Topical delivery of mesenchymal stem cells and their function in wounds. Stem Cell Res Ther. 2010 24;1(4):30. Abstract

Bonfield, T.L.; Koloze, M.; Lennon, D.P.; Zuchowski, B.; Yang, S.E.; and Caplan, A.I.: Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. Am J Physiol Lung Cell Mol Physiol. 2010 299(6):L760-770.Abstract

Caplan, A.I.: What’s in a name? Tissue Engineering Part A 2010, 16(8):2415-2417.Abstract

Bonfield, T.L. and Caplan, A.I.: Adult mesenchymal stem cells: An innovative therapeutic for lung diseases. Discov Med. 2010 9(47):337-345. Abstract

Abrahamsson, C.; Yang, F.; Park, H.; Brunger, J.; Valonen, P.; Langer, R.; Welter, J.; Caplan, A.; Guilak, F.; and Freed L.: Chondrogenesis and mineralization with in vitro culture of human mesenchymal stem cells on 3D-woven scaffolds, Tissue Engineering Part A. 2010 16(12):3709-3718. Abstract

Miller, R.H.; Bai, L.; Lennon, D.P.; and Caplan, A.I.: The potential of mesenchymal stem cells for neural repair. Discovery Medicine 2010 9(46):236-242. Abstract

Valonen, P.K.; Moutos, F.T.; Kusanagi, A.; Moretti, M.; Diekman, B.O.; Welter, J.F.; Caplan, A.I.; Guilak, F.; and Freed, L.E.: In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(ε-caprolactone) scaffolds. Biomaterials 2010 31(8):2193 – 2200. Abstract

Diekman, B.O.; Rowland, C.R.; Lennon, D.P.; Caplan, A.I.; and Guilak, F.: Chondrogenesis of adult stem cells from adipose tissue and bone marrow: Induction by growth factors and cartilage derived matrix. Tiss Engineering Part A 2010, 523-533.

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Influence of adult mesenchymal stem cells on in vitro vascular formation. In: Advances in Tissue Engineering, Volume 1: Angiogenesis. Chapter 24:241-248, 2010.

Caplan, A.I.: Mesenchymal stem cells: The past, the present, the future. Cartilage 2010, 1(1)6-9.

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Diego Correa, M.D., M.Sc., Ph.D.

Somoza, R.A.; Correa, D.; Labat, I.; Sternberg, H.; Forrest, M.E.; Khalil, A.M.; West, M.D.; Tesar, P.; and Caplan, A.I.: Transcriptome-wide analyses of human neonatal articular cartilage and human mesenchymal stem cell-derived cartilage provide a new molecular target for evaluating engineered cartilage. Tissue Engineering, Part A, DOI: 10.1089/ten.tea.2016.0559

Correa D.; Lin, P.; Somoza, R.; Schiemann, W.P.; and Caplan, A.I.: Bone marrow Mesenchymal Stem Cells (BM-MSCs) regulate melanoma cancer cell extravasation at their perivascular niche. International Journal of Cancer, 2016 15;138(2):417-27Abstract

Correa, D.; Somoza, R.A.; Lin, P.; Rom, E.; Duesler, L.; Welter, J.F.; Yayon, A.; and Caplan. A.I.: Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. Osteoarthritis and Cartilage, 2014 pii: S1063-4584(14)01336-3 Abstract

Somoza, R.; Welter, J.; Correa, D.; and Caplan, A.: Chondrogenic differentiation of Mesenchymal Stem Cells: unfulfilled expectations and new challenges. Tissue Engineering part B, April 22, 2014 (Epub ahead of print) Abstract

Lin, P.; Correa, D.; Kean, T.J.; Awadallah, A.; Dennis, J.E.; and Caplan, A.I.: Serial transplantation and long-term engraftment of intra-arterially delivered clonally derived mesenchymal stem cells to injured bone marrow. Molecular Therapy. 2013, 22(1):160-168. Abstract

Kiviranta, R.; Yamana, K.; Saito, H.; Ho, D.K.; Laine, J.; Tarkkonen, K.; Nieminen-Pihala, V.; Hesse, E.; Correa, D.; Määttä, J.; Tessarollo, L.; Rosen, E.D.; Horne, W.C.; Jenkins, N.A.; Copeland, N.G.; Warming, S.; and Baron, R.: Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages. Journal of Experimental Medicine. 2013, 6;210(5):969-85. Abstract

Lin, P.; Lin, Y.; Lennon, D.P.; Correa, D.; Schluchter, M.; and Caplan, A.I.: Efficient lentiviral transduction of human mesenchymal stem cells that preserves proliferation and differentiation capabilities. Stem Cells Translational Medicine 2012, 1(12):886-97. Abstract

Correa, D. and Segal, S.S.: Neurovascular proximity in the diaphragm muscle of adult mice. Microcirculation. 2012, 19(4):306-15. Abstract

Lin, P.; Correa, D.; Lin, Y.; and Caplan, A.I.: Polybrene inhibits human mesenchymal stem cells proliferation during lentiviral transduction. PLoS One. 2011, 6(8): e23891. Abstract

Caplan, A.I. and Correa, D.: The MSC: An injury drugstore. Cell Stem Cell. 2011 9(1): 11-15. Abstract

Caplan, A.I.; and Correa, D.: PDGF in bone formation and regeneration: New insights into a novel mechanism involving MSCs. Journal of Orthopaedic Research. 2011 29(12):1795-1803. Abstract

Correa, D. and Goldberg, V.M.: Stem cells in orthopaedics. American Academy of Orthopaedic Surgery (AAOS). 2011 5(7):41-45.

Seriwatanachai, D.; Densmore, M.; Correa, D.; Baron, R.; and Lanske B.: Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen Metaphyseal Chondrodysplasia. FASEB Journal. 2011 25(9): 3057-3067. Abstract

Hesse, E.; Saito, H.; Kiviranta, R.; Correa, D.; Yamana, K.; Neff, L.; Toben. D; Duda. G.; Atfi, A.; Geoffroy, V.; Horne, W.C.; and Baron, R.: Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity. Journal of Cell Biology 2010 191(7):1271-1283. Abstract

Correa, D.; Hesse, E.; Seriwatanachai, D.; Kiviranta, R.; Saito, H.; Yamana, K.; Neff, L.; Atfi, A.; Coillard, L.; Sitara, D.; Maeda, Y.; Warming, S.; Jenkins, N.A.; Copeland, N.G.; Horne, W.C.; Lanske, B.; and Baron, R.: Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. Dev Cell. 2010 19(4):533-546. Abstract

Hesse, E.; Kiviranta, R.; Wu, M.; Saito, H.; Yamana, K.; Correa, D.; Atfi, A.; and Baron, R.: Zinc finger protein 521, a new player in bone formation. Annals of the New York Academy of Sciences 2010 1192:32-37. Abstract

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Alex Huang, M.D., Ph.D.

Askew, D,; Su, C.A.; Barkauskas, D.S.; Dorand, R.D.; Myers, J.; Liou, R.; Nthale, J.; and Huang, A.Y.: Transient surface CCR5 expression by naive CD8+ T cells within inflamed lymph nodes is dependent on high endothelial venule interaction and augments Th Cell-dependent memory response. J Immunol. 2016 196(9):3653-64. Abstract

Wang, W.; Zimmerman, G.; Huang, X.; Yu, S.; Myers, J.; Wang, Y.; Moreton, S.; Nthale, J.; Awadallah, A.; Beck, R.; Xin, W.; Wald, D.; Huang, A.Y; and Zhou, L.: Aberrant notch signaling in the bone marrow microenvironment of acute lymphoid leukemia suppresses osteoblast-mediated support of hematopoietic niche function. Cancer Res. 2016 76(6):1641-52. Abstract

Sinyuk, M.; Alvarado, A.G.; Nesmiyanov, P.; Shaw, J.; Mulkearns-Hubert, E.E.; Eurich, J.T.; Hale, J.S.; Bogdanova, A.; Hitomi, M.; Maciejewski, J.; Huang, A.Y.; Saunthararajah, Y.; and Lathia, J.D.: Cx25 contributes to leukemia cell communication and chemosensitivity. Oncotarget. 2015 6(31):31508-21. Abstract

Omenetti, S.; Brogi, M.; Goodman, W.A.; Croniger, C.M.; Eid, S.; Huang, A.Y.; Laffi, G.; Roskams, T.; Cominelli, F.; Pinzani, M.; and Pizarro, T.T.: Dysregulated intrahepatic CD4+ T-cell activation drives liver inflammation in ileitis-prone SAMP1/YitFc mice. Cellular and Molecular Gastroenterology and Hepatology 2015, 1(4):406-419. Abstract

Delvecchio, F.R.; Vadrucci, E.; Cavalcanti, E.; De Santis, S.; Kunde, D.; Vacca, M.; Myers, J.; Allen, F.; Bianco, G.; Huang, A.Y.; Monsurro, V.; Santino, A.; and Chieppa, M.: Polyphenol administration impairs T-cell proliferation by imprinting a distinct dendritic cell maturational profile. European Journal of Immunology 2015, 45(9):2638-2649. doi: 10.1002/eji.201545679. Abstract

Wang, W.; Yu, S.; Zimmerman, G.; Wang, Y.; Myers, J.; Yu, V.W.; Huang, D.; Huang, X.; Shim, J.; Huang, Y.; Xin, W.; Qiao, P.; Yan, M.; Xin, W.; Scadden, D.T.; Stanley, P.; Lowe, J.B.; Huang, A.Y.; Siebel, C.W.; Zhou, L.: Notch receptor-ligand engagement maintains hematopoietic stem cell quiescence and niche retention. Stem Cells 2015, 33(7):2280-2293. doi: 10.1002/stem.2031. Abstract

Sinyuk, M.; Alvarado, A.G.; Nesmiyanov, P.; Shaw, J.; Mulkearns-Hubert, E.E.; Eurich, J.T.; Hale, J.S.; Bogdanova, A.; Hitomi, M.; Maciejewski, J.; Huang, A.Y.; Saunthararajah, Y.; and Lathia, J.D.: Cx25 contributes to leukemia cell communication and chemosensitivity. Oncotarget 2015 (in press).

Evans, T.A.; Barkauskas, D.S.; Myers, J.T.; Hare, E.G.; You, J.Q.; Ransohoff, R.M.; Huang, A.Y.; and Silver, J.: High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury. Exp Neurol. 2014 254:109-120. Abstract

Scrimieri, F.; Askew, D,; Corn, D.J.; Eid, S.; Bobanga, I.D.; Bjelac, J.A.; Tsao, M.L.; Allen, F.; Othman, Y.S.; Wang, S.C.; and Huang, A.Y.: Murine leukemia virus envelope gp70 is a shared biomarker for the high-sensitivity quantification of murine tumor burden. Oncoimmunology. 2013 1;2(11):e26889. Abstract

Barkauskas, D.S.; Evans, T.A.; Myers, J.; Petrosiute, A.; Silver, J.; and Huang, A.Y.: Extravascular CX3CR1+ cells display intraluminal dendritic protrusions into intact CNS vessel lumen. Microscopy Microanal. 2013 19(4):778-790. Abstract

Myers, J.; Barkauskas, D.; and Huang, A.Y.: Dynamic single-cell imaging of marrow-resident lysozyme-expressing myeloid cells with human mesenchymal stem cells upon systemic lipopolysaccharide challenge. Stem Cell International. 2013:656839. Abstract

Nesmiyanov, P.; Bogdanova, A.; Huang, A.Y.; Hitomi, M.; and Lathia, J.D.: Single cell analysis reveals homocellular communication between leukemia cells. BMC Cancer. (Under review)

Huang, A.Y.; Haining, W.N.; Barkauskas, D.S.; Myers, J.T.; Petrosiute, A.; Garrett, A.P.; Singh, K.; Cooke, K.R.; and Kean, L.S.: Viewing transplantation immunology through today’s lens: New models, new imaging, and new insights. Biol. Blood Marrow Transplant 2013 19:S44-s51. Abstract

Mandl, J.N.; Liou, R.; Klauschen, F.; Vrisekoop, N.; Monteiro, J.P.; Yates, A.J.; Huang, A.Y.; and Germain, R.N.: Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naive CD4+ and CD8+ T cells. PNAS 2012, 109:18036-18041. Abstract

Huang, A.Y.; Myers, J.T.; Barkauskas, D.; Howell, S.J.; Oleinick, N.L.; McCormick, T.S.; Cooper, K.D.; Baron, E.D.; and Lam, M.: Cutaneous penetration of the topically applied photosensitizer Pc 4 as detected by intravital 2-photon laser scanning microscopy. Photodiagnosis Photodyn Ther. 2012 9:225-231. Abstract

Liou, H.L.; Myers, J.T.; Barkauskas, D.S.; and Huang, A.Y.: Intravital imaging of the mouse popliteal lymph node. J. Vis Exp. 2012 doi:pii:3720. 10.3791/3720 Abstract

Lathia, J.D.; Gallagher, J.; Myers, J.T.; Li, M.; Vasanji, A.; McLendon, R.E.; Hjelmeland, A.B.; Huang, A.Y.; and Rich, J.N.: Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells. PLoS One 2011 6:e24807. Abstract

Pareek, T.K.; Lam, E.; Zheng, X.; Askew, D.; Kulkarni, A.B.; Chance, M.R.; Huang, A.Y.; Cooke, K.R.; and Letterio, J.J.: Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis. J. Exp. Med. 2010 207:2507-2019. Abstract

Huang, A.Y.: Bulging glands? Blame it on B cells. Blood 2010 115:4624-4626. Abstract

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Jonathan E. Kenyon, Ph.D.

Verbus, E.A.; Kenyon, J.D.; Sergeeva, O.; Awadallah, A.; Yuan, L.; Welter, J.F.; Caplan, A.I.; Schluchter, M.D.; Khalil, A.M.; and Lee, Z.: Expression of miR-145-5p during chondrogenesis of mesenchymal stem cells 2017 (Submitted to Stem Cells and Translational Medicine)

Kenyon, J.; Nickel-Meester, G.; Qing, Y.; Santos-Guasch, G.; Drake, E.; PingfuFu, S.S.; Bai, X.; Wald, D.; Arts, E.; and Gerson, S,L.: Epigenetic Loss of MLH1 Expression in Normal Human Hematopoietic Stem Cell Clones is Defined by the Promoter CpG Methylation Pattern Observed by High-Throughput Methylation Specific Sequencing. Int J Stem Cell Res Ther. 2016;3(2). pii: 031. Abstract

Rivera-Delgado, E.; Sadeghi, Z.; Wang, N.X.; Kenyon, J.; Satyanarayan, S.; Kavran, M.; Flask, C.; Hijaz, A.Z.; von Recum, H.A.: Local release from affinity-based polymers increases urethral concentration of the stem cell chemokine CCL7 in rats. Biomed Mater. 2016 11(2):025022. Abstract

Kenyon, J.; Fu, P.; Lingas, K.; Thomas, E.; Saurastri, A.; Santos Guasch, G.; Wald, D.; and Gerson, S.L.: Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age. Blood. 2012; 120(16):3229-36. Abstract

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Ahmad M. Khalil, Ph.D.

Verbus, E.A.; Kenyon, J.D.; Sergeeva, O.; Awadallah, A.; Yuan, L.; Welter, J.F.; Caplan, A.I.; Schluchter, M.D.; Khalil, A.M.; and Lee, Z.: Expression of miR-145-5p during chondrogenesis of mesenchymal stem cells 2017 (Submitted to Stem Cells and Translational Medicine)

Somoza, R.A.; Correa, D.; Labat, I.; Sternberg, H.; Forrest, M.E.; Khalil, A.M.; West, M.D.; Tesar, P.; and Caplan, A.I.: Transcriptome-wide analyses of human neonatal articular cartilage and human mesenchymal stem cell-derived cartilage provide a new molecular target for evaluating engineered cartilage. Tissue Engineering, Part A, DOI: 10.1089/ten.tea.2016.0559

Merry, C.R.; Forrest, M.E.; Sabers, J.N.; Beard, L.; Gao, X.-H.; Hatzoglou, M.; Jackson, M.W.; Wang, Z.; Markowitz, S.D.; and Khalil, A.M.: DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer. Human Molecular Genetics, 2015 24(21):6240-53 Abstract

Merry, C.R.; McMahon, S.; Thompson, C.L.; Miskimen, K.L.; Harris, L.N.; and Khalil, A.M.: Integrative transcriptome-wide analyses reveal critical HER2-regulated mRNAs and lincRNAs in HER2+ breast cancer Breast Cancer Res Treat. 2015 150(2):321-34.Abstract

Morton, M.L.; Bai, X.; Merry, C.R.; Linden, P.A.; Khalil, A.M.; Leidner, R.S.; Thompson, C.L.: Identification of mRNAs and lincRNAs associated with lung cancer progression using next-generation RNA sequencing from laser micro-dissected archival FFPE tissue specimens. Lung Cancer. 2014 85(1):31-39. Abstract

Mazar, J.; Zhao, W.; Khalil, A.M.; Lee, B.; Shelley, J.; Govindarajan, S.; Yamamoto, F.; Ratnam, M.; Aftab, M.N.; Collins, S.; Finck, B.N.; Han, X.; Mattick, J.S.; Dinger, M.E.; Perera, R.J.: The functional characterization of the long noncoding RNA SPRY4-IT1 in human melanoma cells. Oncotarget. 2014 5(19):8959-8969. Abstract

Merry, C.R.; Niland, C.; and Khalil, A.M.: Diverse functions and mechanisms of mammalian long noncoding RNAs. Methods Mol Biol. 2015 1206:1-14. Abstract

Mustafi, D.; Kevany, B,; Bai, X.; Maeda, T.; Khalil, A.M.; and Palczewski; K.: Evolutionary conserved long intergenic non-coding RNAs in the eye. Human Molecular Genetics. 2013 22(15):2992-3002 Abstract

Factor, D.; Tesar, P.J.; and Khalil, A.M.: Chromatin regulation by long non-coding RNAs in: Molecular Biology of Long Non-coding RNAs, Khalil, A. and Coller, J. Eds. Springer, 2013. ISBN-13: 978-1461486206

Geisler, S.; Lojek, L.; Khalil, A.M.; Baker, K.; and Coller, J.: Decapping of long non-coding RNAs regulate inducible genes. Mol Cell. 2012 45(3):279-91. Abstract

Moran VA, Perera R, and Khalil AM(2012). Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs. Nucleic Acid Research. 2012 40(14):6391-400. Abstract

Moran VA, Niland C and Khalil AM.(2012). Co-immunoprecipitation of long non-coding RNAs. Methods in Molecular Biology. 2012 925:219-228. Abstract

Niland, C.N.; Merry, C.R.; and Khalil, A.M.: Emerging roles for long non-coding RNAs in cancer and neurological disorders. Front Genet. 2012 3-25:1-8 Abstract

Khalil, A.M. and Rinn, J.L.: RNA-protein interactions in human health and disease. Semin Cell Dev Biol. 2011 22(4):359-65. Abstract

Huarte, M.; Guttman, M.; Feldser, D.; Garber, M.; Khalil, A.M.; Zuk, O.; Amit, I.; Regev, A.; Lander, E.S.; Jacks, T.; and Rinn, J.L.: A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 transcriptional response. Cell. 2010 142(3):409-19. Abstract

Khalil, A.M. and Driscoll, D.J.: Epigenetic Regulation of Pericentromeric Heterochromatin during Mammalian Meiosis. Cytogenetics and Genome Research. 2010 129(4):280-289Abstract

Khalil, A.M.; Huarte, M.; and Rinn, J.L.: The Emerging Non-coding RNA world. Book Title: MicroRNAs in Development and Cancer. Imperial College Press. Editor: Frank Slack, Yale University. 2010 (Invited Book Chapter)

Getun, I.; Wu, Z.K.; Khalil, A.M.; and Bois, P.R.: The chromatin architecture of mouse recombination hotspots. EMBO Reports. 2010 11(7):555-560. Abstract

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Zhenghong Lee, Ph.D.

Verbus, E.A.; Kenyon, J.D.; Sergeeva, O.; Awadallah, A.; Yuan, L.; Welter, J.F.; Caplan, A.I.; Schluchter, M.D.; Khalil, A.M.; and Lee, Z.: Expression of miR-145-5p during chondrogenesis of mesenchymal stem cells 2017 (Submitted to Stem Cells and Translational Medicine)

Prologo, J.D.; Hawkins, M.; Gilliland, C.; Chinnadurai, R.; Harkey, P.; Chadid, T.; Lee, Z.; and Brewster, L.: Interventional stem cell therapy. Clin Radiol. 2016 71(4):307-11.Abstract

Mansour, J.; Lee, Z.; and Welter, J.: Nondestructive techniques to evaluate the characteristics and development of engineered cartilage. (Invited review). Annals of Biomedical Engineering 2016 44(3):733-49. Abstract

Choe, H,; Narayanan, A.; Lee, Z.; Bonomo, R.; Weinberg, A.; Gandhi, D.; Marcus, R.; and Greenfield, E.: Immunomodulatory peptide that decreases infection and preserves osseointegration. Clinical Orthopaedics and Related Research 2015, doi: 10.1007/s11999-015-4301-2. Abstract

Peiris, P.M.; Deb, P.; Doolittle, E.; Doron,G.; Goldberg, A.; Govender, P.; Shah, S.; Rao, S.; Carbone, S.; Cotey, T.; Sylvestre, M.; Singh, S.; Schiemann, W.P.; Lee, Z.; Karathanasis, E.: Vascular targeting of a gold nanoparticle to breast cancer metastasis. Journal of Pharmaceutical Sciences 2015, 104:2600–2610. PMCID: PMC4504827Abstract

Wang, F.J.; Eid, S.; Dennis, J.E.; Cooke, K.R.; Auletta, J.J.; and Lee, Z.: Route of delivery influences biodistribution of human bone marrow-derived mesenchymal stromal cells following experimental bone marrow transplantation. Journal of Stem Cells and Regenerative Medicine 2015, 11(2):1-10

Auletta, J.J.; Eid, S.K.; Wuttisarnwattana, P.; Silva, I.; Metheny, L.; Keller, M.D.; Guardia-Wolff, R.; Liu, C.; Wang, F.; Bowen, T.; Lee, Z.; Solchaga, L.A.; Ganguly, S.; Tyler, M.; Wilson, D.L.; and Cooke, K.R: Human mesenchymal stromal cells attenuate graft-versus-host disease and maintain graft-versus-leukemia activity following experimental allogeneic bone marrow transplantation. Stem Cells. 2014 33(2):601-14 Abstract

Valls, L.; Hoimes, C.; Sher, A.; Hu, L.; Lee, Z.; Muzic, R. and Avril, N.: Early response monitoring of receptor tyrosine kinase inhibitor therapy in metastatic renal cell carcinoma using [18F]FLT-PET/MR. Seminar in Roentgenology 2014 49(3):238-41Abstract

Lee, Z. and Luo, G. Issues pertaining to PET imaging of liver cancer. J Fasting Health. 2014; 2(2):62-64. Abstract

Partovi, S.; Kohan, A.; Rubbert, C.; Vercher-Conejero, J.L.; Gaeta, C.; Yuh, R.; Zipp, L.; Herrmann, K.; Robbin, M.R.; Lee, Z.; Muzic, R.F.; Faulhaber, P.; and Ros, P.R.: Clinical oncologic applications of PET/MRI: A new horizon. American Journal of Nuclear Medicine and Molecular Imaging 2014 4(2):202-12 Abstract

Kuang, Y.; Wang, F.; Corn, D.; Tian, H.; and Lee, Z.: In vitro characterization of uptake mechanism of L-[methyl-3H]-methionine in hepatocellular carcinoma. Molecular Imaging and Biology 2014 16(4):459-68 Abstract

Kuang, Y.; Wang, F.; Corn, D.J.; Tian, H.; and Lee, Z.: Metabolism of radiolabeled methionine in hepatocel-lular carcinoma. Molecular Imaging and Biology 2014, 16(1):44-52. Abstract

Bonsignore, L.A.; Anderson, J.R.; Lee, Z.; Goldberg, V.M.; and Greenfield, E.M.: Adherent lipopolysaccharide inhibits the osseointegration of orthopedic implants by impairing osteoblast differentiation. Bone 2013 52(1):93-101. Abstract

Prologo, J.D.; Pirasteh, A.; Tenley, N.; Yuan, L.; Corn, D.; Hart, D.; Love, Z.; Lazarus, H.M.; and Lee, Z.: Percutaneous image-guided delivery for the transplantation of mesenchymal stem cells in the setting of degenerated intervertebral discs. Journal of Vascular and Interventional Radiology 2012 23(8):1084-1088. Abstract

Lee, Z.; Dennis, J.; Welter, J.; and Caplan, A.: Imaging stem cell differentiation for cell-based tissue repair. Methods in Enzymology 2012 506:247-263. Abstract

Tian, H.; Lu, X.; Guo, H.; Corn, D.; Molter, J.; Wang, B.; Luo, G.; Lee, Z.: Radio-deoxynucleoside analogs used for imaging tk expression in a transgenic mouse model of induced hepatocellular carcinoma. Theranostics 2012 2(6):597-606. Abstract

Merritt, S.R.; Exner, A.A.; Lee, Z.; and von Recum, H.A.: Electrospinning and Imaging. Advanced Biomaterials 2012 14(5):B266-B278.

Andres Ibarra, R.; Abbas, R.; Kombu, R.S.; Zhang, G.F.; Jacobs, G.; Lee, Z.; Brunengraber, H.; and Sanabria, J.R.: Disturbances in the glutathione/ophthalmate redox buffer system in the woodchuck model of hepatitis virus-induced hepatocellular carcinoma. HPB Surg. 2011:789323. Abstract

Lu, X.; Guo, H.; Molter, J.; Miao, H.; Gerber, L.; Hu, Y.; Barnes, E.L.; Vogel, H.; Lee, Z.; Luo, G.; and Wang, B.: Alpha-fetoprotein-thymidine kinase-luciferase knockin mice: a novel model for dual modality longitudinal imaging of tumorigenesis in liver. Journal of Hepatology 2011 55(1):96-102. Abstract

Kolthammer, J.A.; Corn, D.J.; Tenley, N.; Wu, C.; Tian, H.; Wang, Y.; and Lee, Z.: PET imaging of hepatocellular carcinoma with 18F-fluoroethylcholine and 11C-choline. Eur J Nucl Med Mol Imaging 2011 38(7):1248-1256. Abstract

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Donald P. Lennon, D.D.S.

Sutton, M.T.; Fletcher, D.; Ghosh, S.K.; Weinberg, A.; van Heeckeren, R.; Kaur, S.; Sadeghi, Z.; Hijaz, A.; Reese, J.; Lazarus, H.M.; Lennon, D.P.; Caplan, A.I.; and Bonfield, T.L.: Antimicrobial properties of mesenchymal stem cells: therapeutic potential for cystic fibrosis infection, and treatment. Stem Cells Int. 2016;2016:5303048. Abstract

Wallace, J.; Wang, M.O.; Thompson, P.; Busso, M.; Belle, V.; Mammoser, N.; Kim, K.; Fisher, J.P.; Siblani, A.; Xua, Y.; Welter, J.F.; Lennon, D.P.; Sun, J.; Mikos, A.G.; Caplan, A.I.; Dean, D.: Validating continuous digital light processing (cDLP) additive manufacturing accuracy and tissue engineering utility of a dye-initiator package. Biofabrication 2014 6(1) Abstract

Rowland, C.R.; Lennon, D.P.; Caplan, A.I.; and Guilak. F.: The effects of crosslinking of scaffolds engineered from cartilage ECM on the chondrogenic differentiation of MSCs. Biomaterials. 2013 34(23):5802-5812. Abstract

Crapnell, K.; Blaesius, R.; Hastings, A.; Lennon, D.P.; Caplan, A.I.; and Bruder, S.P.: Growth, differentiation capacity, and function of mesenchymal stem cells expanded in serum-free medium developed via combinatorial screening. Exp Cell Res. 2013 319(10):1409-1418. Abstract

Lin, P.; Lin, Y.; Lennon, D.P.; Correa, D.; Schluchter, M.; and Caplan, A.I.: Efficient lentiviral transduction of human mesenchymal stem cells that preserves proliferation and differentiation capabilities. Stem Cells Transl Med. 2012 1(12):886-897. Abstract

Lennon, D.P.; Schluchter, M.D.; and Caplan, A.I.: The effect of extended first passage culture on the proliferation and differentiation of human marrow-derived mesenchymal stem cells. Stem Cells Transl Med. 2012 1(4):279-288. Abstract

Ousema, P.H.; Moutos, F.T.; Estes, B.T.; Caplan, A.I.; Lennon, D.P.; Guilak, F,; and Weinberg, J.B.: The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds. Biomaterials. 2012 33(35):8967-8974. Abstract

Bai, L.; Lennon, D.P.; Caplan, A.I.; DeChant, A.; Hecker, J.; Kranso, J.; Zaremba, A.; and Miller, R.H.: Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models. Nat Neurosci. 2012 15(6):862-870. Abstract

Bonfield, T.L.; Nolan Koloze, M.T.; Lennon, D.P.; and Caplan, A.I.: Defining human mesenchymal stem cell efficacy in vivo. J Inflamm (Lond). 2010, 25;7:51. Abstract

Bonfield, T.L.; Koloze, M.; Lennon, D.; Zuchowski, B.; Yang, S.E.; and Caplan,A.I.: Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. Am J Physiol Lung Cell Mol Physiol, 2010 Dec;299(6):L760-70. Abstract

Miller, R.H.; Bai, L.; Lennon, D.P.; and Caplan, A.I.: The potential of mesenchymal stem cells for neural repair. Discov Med. 2010 9(46):236-242. Abstract

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Ming Li, Ph.D.

Demory Beckler, M.; Higginbotham, J.N.; Franklin, J.L.; Ham, A.J.; Halvey, P.J.; Imasuen, I.E.; Whitwell, C.; Li, M.; Liebler, D.C.; and Coffey, R.J.: Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Mol Cell Proteomics. 2013 12(2):343-55. Abstract

Kim, H.J.; Lin, D.; Lee, H.J.; Li, M.; and Liebler, D.C.: Quantitative profiling of protein tyrosine kinases in human cancer cell lines by multiplexed parallel reaction monitoring assays. Mol Cell Proteomics. 2016 15(2):682-91. Abstract


Joseph M. Mansour, Ph.D.

Verbus, E.A.; Kenyon, J.D.; Sergeeva, O.; Awadallah, A.; Yuan, L.; Welter, J.F.; Caplan, A.I.; Schluchter, M.D.; Khalil, A.M.; and Lee, Z.: Expression of miR-145-5p during chondrogenesis of mesenchymal stem cells 2017 (Submitted to Stem Cells and Translational Medicine)

Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. (Submitted)

Whitney, G.A.; Kean, T.J.: Fernandes, R.J.; Waldman, S.; Tse, M.Y.; Pang, S.C.; Mansour, J.M.; and Dennis, J.E.:
Thyroxine increases collagen type II expression and accumulation in scaffold-free tissue-engineered articular cartilage. Tissue Eng Part A. 2017 doi: 10.1089/ten.TEA.2016.0533. [Epub ahead of print]Abstract

Kumar, D.; Moore, R.M.; Mercer, B.M.; Mansour, J.M.; Redline, R.W.; and Moore, J.J.: The physiology of fetal membrane weakening and rupture: Insights gained from the determination of physical properties revisited. Placenta. 2016, 42:59-73. doi: 10.1016/j.placenta.2016.03.015.Abstract

Zhou,H.; Gawlik, A.; Hernandez, C.; Goss, M.; Mansour,J.; and Exner, A.: Nondestructive characterization of biodegradable polymer erosion in vivo using ultrasound elastography imaging ACS Biomater. Sci. Eng. 2016 (Accepted)

Mansour, J.; Lee, Z.; and Welter, J.: Nondestructive techniques to evaluate the characteristics and development of engineered cartilage. (Invited review). Annals of Biomedical Engineering. 2016 44(3):733-749. Abstract

Zhou, H.; Goss, M.; Hernandez, C.; Mansour, J.M.; and Exner, A.: Validation of ultrasound elastography imaging for nondestructive characterization of stiffer biomaterials. Annals of Biomedical Engineering. 2016 44(5):1515-1523. Abstract

Chung, C.Y.; Heebner, J.; Baskaran, H.; Welter, J.F.; and Mansour, J.M.: Ultrasound elastography for estimation of regional strain of multilayered hydrogels and tissue-engineered cartilage. Annals of Biomedical Engineering. 2015 43(12):2991-2300Abstract

Kumar, D.; Springel, E.; Moore, R.M.; Mercer, B.M.; Philipson, E.; Mansour, J.M.; Mesiano, S.; Schatz, F.; Lockwood, C.J.; and Moore, J.J.: Progesterone inhibits in vitro fetal membrane weakening. American Journal of Obstetrics and Gynecology 2015, pii: S0002-9378(15)00597-9. doi: 10.1016/j.ajog.2015.06.014. Abstract

Whitney, G.A.; Mansour, J.M.; and Dennis, J.E.: Coefficient of friction can identify damage in native and engineered cartilage subjected to frictional-shear stress. Annals of Biomedical Engineering. 2015 43(9):2056-2068Abstract

Chung, C.-Y. and Mansour, J.M.: Determination of poroelastic properties of cartilage using constrained optimization coupled with finite element analysis. Journal of the Mechanical Behavior of Biological Materials. 2015 42:10-18. Abstract

Moore, R.M.; Nash, A.; Springel, E.; Mercer, B.; Philipson, E.; Mansour, J.; and Moore, J.: Decidual GM-CSF may be a critical common intermediate necessary for Thrombin and TNF induced in-vitro Fetal Membrane Weakening. Placenta. 2014 35(12):1049-1056. Abstract

Motavalli, M.; Akkus, O.; and Mansour, J.M.: Depth-dependent shear behavior of bovine articular cartilage: relationship to structure. J Anat. 2014 225(5):519-526. Abstract

Mansour, J.M.; Gu, D.-W.; Chung, C.-Y.; Heebner, J.; Althans, J,; Abdalian, S.; Schluchter, M.D.; Liu, Y,; and Welter, J.F.: Towards the feasibility of using ultrasound to determine mechanical properties of tissues in a bioreactor. Annals of Biomedical Engineering 2014 42(10):2190-2202. Abstract

Whitney, G.A.; Jayaraman, K.; Dennis, J.E.; and Mansour, J.M.: Scaffold-free cartilage subjected to frictional shear stress demonstrates damage by cracking and surface peeling. J Tissue Eng Regen Med. 2014 doi: 10.1002/term.1925. [Epub ahead of print] Abstract

Motavalli, M.; Whitney, G.A.; Dennis, J.E.; and Mansour, J.M.: Investigating a continuous shear strain function for depth-dependent properties of native and tissue engineering cartilage using pixel-size data. Journal of the Mechanical Behaviour of Biomedical Materials. 2013 28:62-70. Abstract

Chung, C.-Y. and Mansour, J.M.: Using regression models to determine the poroelastic properties of cartilage. Journal of Biomechanics. 2013 46(11):1921-1927. Abstract

Puthiyachirakkal, M.; Lemerand, K.; Kumar, D.; Moore, R.; Philipson, E.; Mercer, B.M.; Mansour, J.M.; Hauguel-de Mouzon, S.; and Moore, J.J.: Thrombin weakens the amnion extracellular matrix (ECM) directly rather than through protease activated receptors. Placenta. 2013 34(10):924-931. Abstract

Kumar, D.; Moore, R.M.; Schatz, F.; Mercer, B.M.; Ragaswamy, N.; Mansour, J.M.; Lockwood, C.J.; and Moore, J.J.: The effects of thrombin and cytokines upon the biomechanics and remodeling of isolated amnion, in vitro. Placenta 32(3):206-213. Abstract

Mansour, J.M. and Welter, J.F.: Multimodal evaluation of tissue-engineered cartilage. Journal of Medical and Biological Engineering 2013 33(1):1-16. Abstract

Chung, C.-Y. and Mansour, J.M.: Application of ANSYS to the stress relaxation of articular cartilage in unconfined compression. Journal of the Chinese Institute of Engineers. 2012 DOI:10.1080/02533839.2013.781795

Whitney, G.A.; Mera, H.; Weidenbecher, M.; Awadallah, A.; Mansour, J.M.; and Dennis, J.E.: Methods for producing scaffold-free engineered cartilage sheets from auricular and articular chondrocyte cell sources and attachment to porous tantalum. BioResearch. 2012 1(4):157-165. Abstract

Walker, J.M.; Myers, A.M.; Schluchter, M.D.; Goldberg, V.M.; Caplan, A.I.; Berilla, J.A.; Mansour, J.M.; and Welter, J.F.: Nondestructive evaluation of hydrogel mechanical properties using ultrasound. Annals of Biomed Eng. 2011 39(10):2521-2530. Abstract

Whitney, G.A.; Mansour, J.M.; and Dennis, J.E.: Cellularity of scaffold-free engineered cartilage is depth dependent. Case Orthopaedic Journal. 2011 8(1):29-31. Link

Rangaswamy, N.; Abdelrahim, A.; Moore, R.; Mercer, B.; Mansour, J.; Redline, R.; Kumar, D.; and Moore, J.: Biomechanical characteristics of human fetal membranes. Preterm fetal membranes are stronger than term fetal membranes. Gynécologie Obstétrique & Fertilité 2011 39(6):373-377. Abstract

Strohl, A.; Kumar, D.; Shaniuk, P.; Smith, J.; Bryant, K.; Novak, J.; Stetzer, B.; Mercer, B.M.; Mansour, J.M.; and Moore, J.J.: Decreased adherence and spontaneous separation of fetal membrane layers–amnion and choriodecidua—a possible part in the normal weakening process. Placenta 2010 31(1):18-24. Abstract

Mercer, B.M.; Abdelrahim, A.; Moore, R.M.; Novak, J.; Kumar, D.; Mansour, J.M.; Perez-Fournier, M.; Milluzzi, C.J.; and Moore J.J.: The impact of Vitamin C supplementation in pregnancy and in-vitro upon fetal membrane strength and remodeling. Reproductive Sciences 2010 17(7):685-695. Abstract

Moore, R.M.; Schatz, F.; Kumar, D.; Mercer, B.M.; Abdelrahim, A.; Rangaswamy, N.; Bartel, C.; Mansour, J.M.; Lockwood, C.J.; and Moore, J.J.: Alpha-lipoic acid inhibits thrombin-induced fetal membrane weakening in vitro. Placenta, 2010 31(10):886-892. Abstract

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Mostafa Motavalli, Ph.D.

Motavalli, M.; Akkus, O.; and Mansour, J.M.: Depth-dependent shear behavior of bovine articular cartilage: relationship to structure. J Anat. 2014 225(5):519-526. Abstract

Motavalli, M.; Whitney, G.A.; Dennis, J.E.; and Mansour, J.M.: Investigating a continuous shear strain function for depth-dependent properties of native and tissue engineering cartilage using pixel-size data. Journal of the Mechanical Behaviour of Biomedical Materials. 2013 28:62-70. Abstract

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Mark Schluchter, M.S., Ph.D.

Verbus, E.A.; Kenyon, J.D.; Sergeeva, O.; Awadallah, A.; Yuan, L.; Welter, J.F.; Caplan, A.I.; Schluchter, M.D.; Khalil, A.M.; and Lee, Z.: Expression of miR-145-5p during chondrogenesis of mesenchymal stem cells 2017 (Submitted to Stem Cells and Translational Medicine)

Cummings, L.C.; Kou, T.D.; Schluchter, M.D.; Chak, A.; and Cooper, G.S. Outcomes after endoscopic versus surgical therapy for early esophageal cancers in an older population. Gastrointest Endosc. 2016 Jan 19. pii: S0016-5107(16)00045-6. doi: 10.1016/j.gie.2016.01.019. [Epub ahead of print] Abstract

Meropol, N.J.; Wong, Y.N.; Albrecht, T.; Manne, S.; Miller, S.M.; Flamm, A.L.; Benson, A.B. 3rd; Buzaglo, J.; Collins. M.; Egleston, B.; Fleisher, L.; Katz, M.; Kinzy, T.G.; Liu, T.M.; Margevicius, S. Miller, D.M.; Poole, D.; Roach, N.; Ross, E.; and Schluchter, M.D.: Randomized trial of a web-based intervention to address barriers to clinical trials. J Clin Oncol. 2016 Feb 10;34(5):469-78 Abstract

Wong, Y.N.; Schluchter, M.D.; Albrecht, T.L.; Benson, A.B. 3rd; Buzaglo, J.; Collins, M.; Flamm, A.L.; Fleisher, L.; Katz, M.; Kinzy, T.G.; Liu, T.M.; Manne, S.; Margevicius, S.; Miller, D.M.; Miller, S.M.; Poole, D.; Raivitch, S.; Roach, N.; Ross, E.; and Meropol, N.J.: Financial concerns about participation in clinical trials among patients with cancer. J Clin Oncol. 2016 34(5):479-87. Abstract

Cooper, G.S.; Kou, T.D.; Schluchter, M.D.; Dor, A.; and Koroukian, S.M.: Changes in receipt of cancer screening in medicare beneficiaries following the affordable care act. J Natl Cancer Inst. 2015 108(5) Abstract

Ma, D.; Pierre, E.Y.; Jiang, Y.; Schluchter, M.D.; Setsompop, K.; Gulani, V.; and Griswold, M.A.: Music-based magnetic resonance fingerprinting to improve patient comfort during MRI examinations. Magnetic Resonance in Medicine 2015, doi: 10.1002/mrm.25818. Abstract

Meyers, J.D.; Cheng, Y.; Broome, A.M.; Agnes, R.S.; Schluchter, M.D.; Margevicius, S.; Wang, X.; Kenney, M.E.; Burda, C.; and Basilion, J.P.: Peptide-Targeted gold nanoparticles for photodynamic therapy of brain cancer. Particle and Particle Systems Characterization 2015, 32(4):448-457. Abstract

Chen, Y.; Lee, G.R.; Wright, K.L.; Badve, C.; Nakamoto, D.; Yu, A.; Schluchter, M.D.; Griswold, M.A.; Seiberlich, N.; and Gulani, V.: Free-breathing liver perfusion imaging using 3-dimensional through-time spiral generalized autocalibrating partially parallel acquisition acceleration. Investigative Radiology 2015, 50(6):367-75. doi: 10.1097/RLI.0000000000000135. Abstract

Bradley Palmer, J.; Lane, D.; Mayo, D.; Schluchter, M.; and Leeming, R.: Effects of music therapy on anesthesia requirements and anxiety in women undergoing ambulatory breast surgery for cancer diagnosis and treatment: A randomized controlled trial. Journal of Clinical Oncology 2015, pii: JCO.2014.59.6049. Abstract

Koroukian, S.M.; Bakaki, P.M.; Han, X.; Schluchter, M.; Owusu, C.; Cooper, G.S.; and Flocke, S.A.: Lasting effects of the breast and cervical cancer early detection program on breast cancer detection and outcomes, Ohio, 2000-2009. Preventing Chronic Disease 2015, 12:E116. doi: 10.5888/pcd12.140491.Abstract

Mansour, J.M.; Gu, D.-W.; Chung, C.-Y.; Heebner, J.; Althans, J,; Abdalian, S.; Schluchter, M.D.; Liu, Y,; and Welter, J.F.: Towards the feasibility of using ultrasound to determine mechanical properties of tissues in a bioreactor. Annals of Biomedical Engineering 2014 42(10):2190-2202. Abstract

Mounts, T.; Ginley, N.; Schluchter, M.; and Dennis, J.E.: Optimization of the expansion and differentiation of rabbit chondrocytes in vitro. Cartilage 2012 3(2):181-187.

Cooper, G.S.; Xu, F.; Schluchter, M.D.; Koroukian, S.M.; and Barnholtz Sloan, J.S.: Diverticulosis and the risk of interval colorectal cancer. Dig Dis Sci. 2014 59(11):2765-2772. Abstract

Partovi, S.; Kohan, A.; Vercher-Conejero, J.L.; Rubbert, C.; Margevicius, S.; Schluchter, M.D.; Gaeta, C.; Faulhaber, P.; and Robbin, M.R.: Qualitative and quantitative performance of ¹8F-FDG-PET/MRI versus ¹8F-FDG-PET/CT in patients with head and neck cancer. AJNR Am J Neuroradiol. 2014 35(10):1970-1975. Abstract

Kershah, S.; Partovi, S.; Traughber, B.J.; Muzic, R.F. Jr; Schluchter, M.D.; O’Donnell, J.K.; and Faulhaber, P.: Comparison of standardized uptake values in normal structures between PET/CT and PET/MRI in an oncology patient population. Mol Imaging Biol. 2013 15(6):776-785. Abstract

Cooper, G.S.; Kou, T.D.; Barnholtz Sloan, J.S.; Koroukian, S.M.; and Schluchter, M.D.: Use of colonoscopy for polyp surveillance in Medicare beneficiaries. Cancer 2013 119(10):1800-1807. Abstract

Lin, P.; Lin, Y.; Lennon, D.P.; Correa, D.; Schluchter, M.; and Caplan, A.I.: Efficient lentiviral transduction of human mesenchymal stem cells that preserves proliferation and differentiation capabilities. Stem Cells Transl Med. 2012 1(12):886-897. Abstract

Lennon, D.P.; Schluchter, M.D.; and Caplan, A.I.: The effect of extended first passage culture on the proliferation and differentiation of human marrow-derived mesenchymal stem cells. Stem Cells Translational Medicine 2012 1:279-288. Abstract

Walker, J.M.; Myers, A.M.; Schluchter, M.D.; Goldberg, V.M.; Caplan, A.I.; Berilla, J.A.; Mansour, J.M.; and Welter, J.F.: Nondestructive Evaluation of Hydrogel Mechanical Properties Using Ultrasound. Annals of Biomedical Engineering 2011, 39(10):2521-2530. Abstract

Lee, R.G.; Vecchiotti, M.A.; Heaphy, J.; Panneerselvam, A.; Schluchter, M.D.; Oleinick, N.L.; Lavertu, P.; Alagramam, K.N.; Arnold, J.E.; Sprecher, R.C.: Photodynamic therapy of cotton-tailed rabbit papilloma virus-induced papillomas in a severe combined immunodeficient mouse xenograft system. The Laryngoscope. 2010 120:618-624. Abstract

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Rodrigo A. Somoza, Ph.D.

Somoza, R.A.; Correa, D.; Labat, I.; Sternberg, H.; Forrest, M.E.; Khalil, A.M.; West, M.D.; Tesar, P.; and Caplan, A.I.: Transcriptome-wide analyses of human neonatal articular cartilage and human mesenchymal stem cell-derived cartilage provide a new molecular target for evaluating engineered cartilage. Tissue Engineering, Part A, DOI: 10.1089/ten.tea.2016.0559

Somoza, R.A.; Correa, D.; Labat, I.; Sternberg, H.; Forrest, M.E.; Khalil, A.M.; West, M.D.; Tesar, P.; and Caplan, A.I.: Human mesenchymal stem cells (MSCs) do not make articular cartilage in vitro: Transcriptome-wide analyses of human neonatal cartilage provide a new molecular target for evaluating engineered cartilage. Tissue Engineering 2017 (Submitted)

Correa D.; Somoza, R.; Lin, P.; Schiemann, W.P.; and Caplan, A.I.: Mesenchymal stem cells regulate melanoma cancer cells extravasation to bone and liver at their perivascular niche. International Journal of Cancer 2016 138(2):417-27 Abstract

Somoza, R.A; Acevedo, C.A.; Weinstein-Oppenheimer, C.; Luz, P.A.; Carrión, F.; and Young, M.E.: TGF-ß3 secretion by human dental follicle mesenchymal stem cells (hDF-MSC) encapsulated in alginate and fibrin scaffolds. Journal of Tissue Engineering and Regenerative Medicine 2015 Tissue Eng Regen Med. doi: 10.1002/term.2004 Abstract

Correa, D.; Somoza, R.A.; Lin, P.; Rom, E.; Duesler, L.; Welter, J.F.; Yayon, A.; and Caplan. A.I.: Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. Osteoarthritis and Cartilage, 2014 pii: S1063-4584(14)01336-3. Abstract

Somoza, R.; Welter, J.; Correa, D.; and Caplan, A.: Chondrogenic differentiation of mesenchymal stem cells: unfulfilled expectations and new challenges. Tissue Engineering part B, April 22, 2014 (Epub ahead of print) Abstract

Acevedo, C.A.; Somoza, R.A.; Weinstein-Oppenheimer, C.; Silva, A.; Moreno, M.; Sanchez, E.; Albornoz, F.; Young, M.E.; MacNaughtan, W.; and Enrione, J. Improvement of human skin cells growth by radiation induced modifications of a Ge/Ch/Ha-scaffold. Bioprocess Biosyst Eng 2013 36:317–324. Abstract

Somoza, R.A. and Rubio, F.J: Cell therapy using induced pluripotent stem cells or somatic stem cells: this is the question. Current Stem Cell Research and Therapy. 2012 7(3):191-196. Abstract

Somoza, R.; Conget, P.; and Rubio, F.J.: Neuropotency of human mesenchymal stem cell cultures: Clonal studies reveal the contribution of cell plasticity and cell contamination. Biology of Blood and Marrow Transplantation 2012 14:546-555. Abstract

Acevedo, C.; Somoza, R.; Weinstein-Oppenheimer, C.; Brown, D.; and Young, M.: Growth factor production from fibrin-encapsulated human keratinocytes. Biotechnology Letters 2010 32:1011–1017. Abstract

Somoza, R.; Juri, C.; Baes, M; Wyneken, U.; and Rubio, F.J.: Intranigral transplantation of epigenetically-induced BDNF-secreting human mesenchymal stem cells: implications for cell-based therapies in Parkinson´s disease. Biology of Blood and Marrow Transplantation 2010 16:1530-1540. Abstract

Enrione, J.; Osorio, F.; López, D.; Weinstein-Oppenheimer, C.; Fuentes, M.A.; Cereani, R.; Brown, D.I.; Albornoz, F.; Sánchez, E.; Villalobos, P.; Somoza, R.A.; Young, M.E.; and Acevedo, C.A.: Characterization of a gelatin/chitosan/hyaluronan scaffold-polymer. Electronic Journal of Biotechnology, 2010 DOI: 10.2225/vol13-issue5-fulltext-15.

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J. Michael Sorrell, Ph.D.

Caplan, A.I. and Sorrell, J.M.: The MSC curtain that stops the immune system. Immunol Lett. 2015 168(2):136-9. Abstract

Sorrell, J.M.; Baber, M.A.; Traktuev, D.O.; March, K.L.; and Caplan, A.I.: The creation of an in vitro adipose tissue that contains a vascular-adipocyte complex. Biomaterials. 2011 32(36):9667-76. Abstract

Carrino, D.A.; Calabro, A.; Darr, A.B.; Dours-Zimmermann, M.T.; Sandy, J.D.; Zimmermann, D.R.; Sorrell, J.M.; Hascall, V.C.; and Caplan, A.I.: Age-related differences in human skin proteoglycans. Glycobiology. 2011, 21(2):257-68. Abstract

Sorrell, J.M. and Caplan, A.I.: Topical delivery of mesenchymal stem cells and their function in wounds. Stem Cell Res Ther. 2010 24;1(4):30. Abstract

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Jean F. Welter, M.D., M.Sc., Ph.D.

Verbus, E.A.; Kenyon, J.D.; Sergeeva, O.; Awadallah, A.; Yuan, L.; Welter, J.F.; Caplan, A.I.; Schluchter, M.D.; Khalil, A.M.; and Lee, Z.: Expression of miR-145-5p during chondrogenesis of mesenchymal stem cells 2017 (Submitted to Stem Cells and Translational Medicine)

Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. (Submitted)

Chou, C.L.; Rivera, A.L.; Williams, V.; Welter, J.F.; Mansour, J.M.; Drazba, J.A.; Sakai, T.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented large-scale tissue engineered cartilage. Acta Biomater. 2017 doi: 10.1016/j.actbio.2017.07.016. [Epub ahead of print] Abstract

Mishra, R.; Sefcik, R.S.; Bishop, T.J.; Montelone, S.M.; Crouser, N.; Welter, J.F.; Caplan, A.I.; and Dean, D.: Growth factor dose tuning for bone progenitor cell proliferation and differentiation on resorbable poly(propylene fumarate) scaffolds. Tissue Engineering Part C Methods. 2016 22(9):904-913. Abstract

Mansour, J.; Lee, Z.; and Welter, J.: Nondestructive techniques to evaluate the characteristics and development of engineered cartilage. (Invited review). Annals of Biomedical Engineering 2016 44(3):733-49. Abstract

Chung, C.Y.; Heebner, J.; Baskaran, H.; Welter, J.F.; and Mansour, J.M.: Ultrasound elastography for estimation of regional strain of multilayered hydrogels and tissue-engineered cartilage. Ann Biomed Eng. 2015 43(12):2991-2300 Abstract

Mansour, J.M.; Gu, D.-W.; Chung, C.-Y.; Heebner, J.; Schluchter, M.D.; and Welter, J.F.: Towards the feasibility of using ultrasound to determine mechanical properties of tissues in a bioreactor. Annals of Biomedical Engineering 2014 42(10):2190-202 Abstract

Correa, D.; Somoza, R.A.; Lin, P.; Greenberg, S.; Rom, E.; Duesler, L.; Welter, J.F.; Yayon, A.; and Caplan, A.I.: Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. Osteoarthritis Cartilage. 2015 23(3):443-53. Abstract

Somoza, R.; Welter, J.; Correa, D.; and Caplan, A.: Chondrogenic differentiation of Mesenchymal Stem Cells: unfulfilled expectations and new challenges. Tissue Engineering part B, 2014 20(6):596-608 Abstract

Prologo, J.D.; Duesler, L.; Berilla,J.A.; Baskaran, H.; Schluchter, M.D.; and Welter, J.F.: Impact of concurrent pressure and shear on MSC viability and differentiation during simulated intervertebral disk needle injection. Journal of Vascular and Interventional Radiology 2014, (Submitted)

Berilla, J. and Welter, J.F.: Image analysis algorithm for measuring shell thickness in engineered cartilage. (in revision)

Penick, K.J.; Solchaga, L.A.; Caplan A.I.; Goldberg, V.M.; and Welter, J.F.: Epitope retrieval for type X collagen detection. (in revision)

Holt, V.; Welter, J.F.; Berilla, J.A.; Harris, M.; and Caplan, A.I.: Cell capture apparatus and staining device. Provisional patent application number 61/875918 filed September 10, 2013.

Wallace, J.; Wang, M.O.; Thompson, P.; Busso, M.; Belle, V.; Mammoser, N.; Kim, K.; Fisher, J.P.; Siblani, A.; Xua, Y.; Welter, J.F.; Lennon, D.P.; Sun, J.; Mikos, A.G.; Caplan, A.I.; Dean, D.: Validating continuous digital light processing (cDLP) additive manufacturing accuracy and tissue engineering utility of a dye-initiator package. Biofabrication 2014 Jan 15;6(1) Abstract

Welter, J.F.; Solchaga, L.A.; Berilla, J.A.; and Penick, K.: Apparatus and method for tissue engineering. US Patent # 8,507,266 issued August 13, 2013.

Mansour, J.M. and Welter, J.F.: Multimodal evaluation of tissue-engineered cartilage. Journal of Medical and Biological Engineering 2013, 33(1):1-16 Abstract

Welter, J.F.; Penick, J.; Solchaga, L.A.: Assessing adipogenic potential of mesenchymal stem cells: a rapid three-dimensional culture screening technique Stem Cells International 2013:806525 Abstract

Bükülmez, H.; Bartels, C.F.; Nanda, K.; Haqqi, T.M.; and Welter, J.F.: Cartilage-protective effects of C-type natriuretic peptide over expression in K/BxN TCR arthritis model. Pediatric Rheumatology 2012, 10(Suppl 1):A109

Chou, C.L.; Rivera, A.L.; Sakai, T.; Caplan, A.I.; Goldberg, V.M.; Welter, J.F.; and Baskaran, H.: Micrometer Scale Guidance of Mesenchymal Stem Cells to Form Structurally Oriented Cartilage Extracellular Matrix. Tissue Eng Part A. 2013 May;19(9-10):1081-90 Abstract

Lee, Z.; Dennis, J.; Welter, J.; and Caplan, A.: Imaging stem cell differentiation for cell-based tissue repair. Methods Enzymol. 2012;506:247-63. Abstract

Shao, Y.Y.; Wang, L.; Welter, J.F.; and Ballock, R.T.: Primary cilia modulate Ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes. Bone 2012, 50(1):79-84. Abstract

Walker, J.M.; Myers, A.M.; Schluchter, M.D.; Goldberg, V.M.; Caplan, A.I.; Berilla, J.A.; Mansour, J.M.; and Welter, J.F.: Nondestructive Evaluation of Hydrogel Mechanical Properties Using Ultrasound. Annals of Biomed Eng. 2011, 39(10):2521-30 Abstract

Sarkar, S.; Bustard, B.L.; Welter, J.F.; and Baskaran, H.: Combined experimental and mathematical approach for development of microfabrication-based cancer migration assay. Annals of Biomedical Engineering 2011, 39(9):2346-59 Abstract

Solchaga, L.A., Penick, K.J.; and Welter, J.F.: Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells: tips & tricks. Chapter in: MSC Assays and Applications. Methods in Molecular Biology. Humana Press, 2011:698:253-278. Abstract)

Auletta, J.J.; Zale, E.A.; Welter, J.; and Solchaga, L.: Fibroblast growth factor-2 enhances expansion of human bone marrow-derived mesenchymal stromal cells without diminishing their immunosuppressive potential. Stem Cells International 2011, Article ID 235176:1 – 10. Abstract

Abrahamsson, C.A.; Yang, F.; Park, H.; Valonen, P.K.; Langer, R.; Welter, J.F.; Caplan, A.I.; Brunger, J.; Guilak, F.; Freed, L.E.: Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on 3D-woven scaffolds. Tissue Engineering, Part A 2010, 16(12):3709 – 3718). Abstract

Liang, W.H.; Kienitz, B.L.; Penick, K.; Welter, J.F.; and Baskaran, H.: Concentrated collagen-chondroitin sulfate scaffolds for tissue engineering applications. Journal of Biomedical Materials Research, Part A 2010 94(4):1050 – 1060. Abstract

Valonen, P.K.; Moutos, F.T.; Kusanagi, A.; Moretti, M.; Diekman, B.O.; Welter, J.F.; Caplan, A.I.; Guilak, F.; and Freed, L.E.: In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(ε-caprolactone) scaffolds. Biomaterials 2010, 31(8):2193 – 2200. Abstract

Solchaga, L.A.; Penick, K.; Goldberg, V.M.; Caplan, A.I.; and Welter, J.F.: Fibroblast growth factor-2 delays the loss of chondrogenic potential in human adult bone marrow-derived mesenchymal stem cells. Tissue Engineering Part A, 2010 16(3):1009-1019 Abstract

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Carl Winalski, M.D.

Patel, R.N.; Kiczek, M.P.; Rubin, B.P.; and Winalski, C.S.: Incidental imaging finding of chest wall mass. Skeletal Radiol. 2015 44(9):1357, 1393-1394. Abstract

Simpfendorfer, C.; Miniaci, A.; Subhas, N.; Winalski, C.S.; and Ilaslan H.: Pseudocyclops: two cases of ACL graft partial tears mimicking cyclops lesions on MRI. Skeletal Radiol. 2015 44(8):1169-73. Abstract

Jones, M.H.; Spindler, K.P.; Fleming, B.C.; Duryea, J.; Obuchowski, N.A.; Scaramuzza, E.A.; Oksendahl, H.L.; Winalski, C.S.; Duong, C.L.; Huston, L.J.; Parker, R.D.; Kaeding, C.C.; Andrish, J.T.; Flanigan, D.C.; Dunn, W.R.; and Reinke, E.K.: Meniscus treatment and age associated with narrower radiographic joint space width 2-3 years after ACL reconstruction: data from the MOON onsite cohort. Osteoarthritis Cartilage. 2015 Jan 3. pii: S1063-4584(14)01392-2 Abstract

Forney, M.C.; Gupta, A.; Minas, T.; and Winalski, C.S.: Magnetic resonance imaging of cartilage repair procedures. Magn Reson Imaging Clin N Am. 2014 Nov;22(4):671-701Abstract

Midura, S.; Schneider, E.; Sakamoto, F.A.; Rosen, G.M.; Winalski, C.S.; and Midura, R.J.: In vitro toxicity in long-term cell culture of MR contrast agents targeted to cartilage evaluation. Osteoarthritis Cartilage. 2014 22(9):1337-45 Abstract

Gupta, A.; Sundaram, M.; and Winalski, C.S.: MRI diagnosis of muscle denervation from herpes zoster with discordant distribution of the skin rash. Skeletal Radiol. 2014 43(10):1481-5. doi: 10.1007/s00256-014-1905-7. Epub 2014 Jun 1. Abstract

Umans, H.; Morrison, W.; DiFelice, G.S.; Vaidya, N.; and Winalski, C.S.: Posterior horn medial meniscal root tear: the prequel. Skeletal Radiol. 2014 43(6):775-80 Abstract

Gupta, A.; Winalski, C.S.;and Sundaram, M.: Neuralgic amyotrophy (Parsonage Turner syndrome). Orthopedics. 2014 Feb;37(2):75, 130-33 Abstract

Ghodadra, A.; Jones, M.H.; Miniaci, A.; and Winalski, C.S.: A method for registration of full-limb radio-graphs to knee MRI. Skeletal Radiol. 2014 43(4):523-8 Abstract

Oak, S.R.; Ghodadra, A.; Winalski, C.S.; Miniaci, A.; and Jones, M.H.: Radiographic joint space width is correlated with 4-year clinical outcomes in patients with knee osteoarthritis: data from the osteoarthritis initiative. Osteoarthritis Cartilage. 2013 21(9):1185-90. Abstract

Sakamoto, F.A.; Winalski, C.S.; Golden, K.L.; and Ready, J.E.: Painful left thigh mass. Skeletal Radiol. 2014 43(1):61-62. Abstract

Shiraj, S.; Winalski, C.S.; Delzell, P.; and Sundaram, M.: Radiologic case study. Intersection syndrome of the wrist. Orthopedics. 2013 36(3):165, 225-227. Abstract

Schub, D.L.; Frisch, N.C.; Bachmann, K.R.; Winalski, C.; and Saluan, P.M.: Mapping of cartilage depth in the knee and elbow for use in osteochondral autograft procedures. Am J Sports Med. 2013 41(4):903-907. Abstract

Bourke, H.E.; Salmon, L.J.; Waller, A.; Winalski, C.S.; Williams, H.A.; Linklater, J.M.; Vasanji, A.; Roe, J.P.; and Pinczewski, L.A.: Randomized controlled trial of osteoconductive fixation screws for anterior cruciate ligament reconstruction: a comparison of the Calaxo and Milagro screws. Arthroscopy. 2013 29(1):74-82. Abstract

Schub, D.L.; Altahawi, F.; Meisel, A.F.; Winalski, C.; Parker, R.D.; and Saluan, P.M.: Accuracy of 3-Tesla magnetic resonance imaging for the diagnosis of intra-articular knee injuries in children and teenagers. J Pediatr Orthop. 2012 32(8):765-769. Abstract

Schub, D.L.; Schmitz, L.M.; Sakamoto, F.A.; Winalski, C.S.; and Parker, R.D.: Long-term outcomes of postoperative septic arthritis after anterior cruciate ligament reconstruction. Am J Sports Med. 2012 40(12):2764-1770. Abstract

Sakamoto, F.A.; Winalski, C.S.; Rodrigues, L.C.; Fernandes, A.R.; Bortoletto, A.; and Sundaram, M.: Radiologic case study. Orthopedics. 2012 35(5):353-437. Abstract

Fritz, J.; Fishman, E.K.; Small, K.M.; Winalski, C.S.; Horger, M.S.; Corl, F.; McFarland, E.; Carrino, J.A.; and Fayad, L.M.: MDCT arthrography of the shoulder with datasets of isotropic resolution: indications, technique, and applications. AJR Am J Roentgenol. 2012 198(3):635-646. Abstract

Freire, M.; Winalski, C.S.; Miniaci, A.; and Sundaram, M.: Radiologic case study. Avulsion of the right adductor longus from the symphysis pubis. Orthopedics. 2012 35(2):85, 158-160. Abstract

Laurens, E.; Schneider, E.; Winalski, C.S.; and Calabro, A.: A synthetic cartilage extracellular matrix model: hyaluronan and collagen hydrogel relaxivity, impact of macromolecular concentration on dGEMRIC. Skeletal Radiol. 2012 41(2):209-217. Abstract

Winalski, C.S. and Rajiah, P.: The evolution of articular cartilage imaging and its impact on clinical practice. Skeletal Radiol. 2011 40(9):1197-1222. Abstract

Sakamoto, F.A.; Winalski, C.S.; Fritchie, K.; Lietman, S.A.; and Sundaram, M.: Radiologic case study. Orthopedics. 2011 34(8):561, 627-631. Abstract

Subhas, N.; Kao. A.; Freire, M.; Polster, J.M.; Obuchowski, N.A.; and Winalski, C.S.: MRI of the knee ligaments and menisci: comparison of isotropic-resolution 3D and conventional 2D fast spin-echo sequences at 3 T. AJR Am J Roentgenol. 2011 197(2):442-450. Abstract

Forney, M.; Subhas, N.; Donley, B.; and Winalski, C.S.: MR imaging of the articular cartilage of the knee and ankle. Magn Reson Imaging Clin N Am. 2011 19(2):379-405. Abstract

Sakamoto, F.A.; Winalski, C.S.; Schils, J.P.; Parker, R.D.; and Polster, J.M.: Vacuum phenomenon: prevalence and appearance in the knee with 3 T magnetic resonance imaging. Skeletal Radiol. 2011 40(10):1275-1285. Abstract

Cole, B.J.; Farr, J.; Winalski, C.S.; Hosea, T.; Richmond, J.; Mandelbaum, B.; De Deyne, P.G.: Outcomes after a single-stage procedure for cell-based cartilage repair: a prospective clinical safety trial with 2-year follow-up. Am J Sports Med. 2011 39(6):1170-1179.Abstract

Forney, M.C.; Winalski, C.S.; and Schils, J.P.: Magnetic resonance imaging of inflammatory arthropathies of peripheral joints. Top Magn Reson Imaging. 2011 22(2):45-59.Abstract

Subhas, N.; Freire, M.; Primak, A.N.; Polster, J.M.; Recht, M.P.; Davros, W.J.; and Winalski, C.S.: CT arthrography: in vitro evaluation of single and dual energy for optimization of technique. Skeletal Radiol. 2010 39(10):1025-1031. Abstract

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